Controlled Trial of Sildenafil in Advanced Idiopathic Pulmonary Fibrosis

Trial published at NEJM
involve 180 pt Advanced Idiopathic Pulmonary Fibrosis (defined as a carbon monoxide diffusion capacity of < 35% of the predicted value)
sildenafil did not cause a significant difference in the proportion of patients with an improvement of 20% or more in the 6-minute walk distance at 12 weeks (the primary outcome). There were small differences favoring sildenafil in some secondary outcomes, including the degree of dyspnea and quality of life.
patients receiving sildenafil during period 1 had symptomatic benefit of arterial blood gas and carbon monoxide diffusion capacity, as compared with placebo-treated patients.
previously published data showing that sildenafil improved ventilation–perfusion matching
Implication:sildenafil was associated with symptomatic improvement may be of value to patients with advanced idiopathic pulmonary fibrosis.

Endovascular versus Open Repair of Abdominal Aortic Aneurysm The United Kingdom EVAR Trial Investigators

Cardiovascular versus Open Repair of Abdominal Aortic Aneurysm
The United Kingdom EVAR Trial Investigators
From 1999 through 2004 at 37 hospitals in the United Kingdom, involving 1252 patients with large abdominal aortic aneurysms (≥5.5 cm in diameter) to undergo either endovascular or open repair; 626 patients for each group.
Follow up 5-10 years.
30-day operative mortality was 1.8% in the endovascular-repair group and 4.3% in the open-repair group
benefit was lost by the end of the study, at least partially because of fatal endograft ruptures.
end of follow-up, there was no significant difference between the two groups in the rate of death from any cause.
CONCLUCION:patients who were considered to be suitable candidates for either endovascular repair or open repair of abdominal aortic aneurysm, the endovascular procedure was associated with a significantly lower operative mortality. However, no significant differences were seen in total mortality or aneurysm-related mortality in the long term. Endovascular repair was associated with increased rates of complications and reinterventions and was more costly

Multiple Beau's Lines

Multiple Beau's Lines as picture above commonly seen in pt undergoing chemotherapy
as cytotoxic chemotherapeutic agents can induce the temporary arrest of proliferative function of the nail matrix.
it may suggest very severe illness too if only single beau's line is seen.
Multiple beaus line almost equal to malignancy with chemotherapy

bilateral ptosis

If you find bilateral ptosis in the patient examined
3 diagnosis must blink in your brain
1) GBS (guillain barre syndrome) if + complete opthalmoplegia then = Miller fischer
Check for ataxia and opthalmoplegia for miller fischer , areflexia for GBS
2) Myasternia grvis demonstrate eyelid fatigue, proximal myopathy fatigue and verbal fatigue(ask pt to count 1-50 continuously)
3) Dystrophy myotonica-demonstrate percussion myotonia at palmar and tongue.
or rare causes-oculopharyngeal dystrophy,
third nerve palsy caused by oculomotor nucleus lesion (rare), multiple sclerosis also may considered but normally presented with internuclear opthalmoplegia and optic atrophy.

Experience in exam:
a lady presented with weakness of bilateral lower limb. Please examine the lower limb.
surprisingly normal tone and power 5/5, reflex absent on jendrassic maneuver
request for gait , cerebellar sign , sensation and gait.
Examiner not keen.
Request to look at the face.
A lady with eyes closed, ask to open eyes demonstate eyes movement -complte opthalmoplegia
want to demonstrate ataxia. stopped by examiner
ask what else to consider -want to demonstrate fatigue of muscle-proceed no fatigue of muscle.
Final diagnosis- miller fischer
ask about feature of miller fischer?
give the famous three-opthalmoplegia, ataxia and areflexia.

Horner syndrome

Horner syndrome
confirm it is horner
"Everything is small"-ptosis,small pupil(miosis),anhydrosis and enolthalmos(occasionally)

proceed to horner protocol
check other cranial nerve to rule out Wallenberg(lateral medullary) syndrome, sensation 5th, facial nerve, gag reflex for 9th and 10th and cerebellar sign plus contralateral sensation .

If no, then look for radiation marking , wasting small muscle , dullness apical ocasionally engorged vessel (Superior vena cava obs) to suggest Pancoast tumour.

dissociated sensory loss and burn scar to suggest syringomyelia if gag reflex reduced than syringobulbia.

surgical scar at neck may suggeast injury to the T1 nerve.

Present the finding .
You should be safe for this station.
(P/S) may sure it is Horner before do all this.

Approach patient with unilateral ptosis

When You see patient with partial ptosis, One of the commonest patient found in neuro station. See whether it is unilateral or bilateral.
for unilateral
The second thing to do is look directly to pupil size,
If pupil size is small then you should enter Horner syndrome protocol which i will explain in my next explaination.
If pupil size is big then , it is third nerve palsy(a surgical third nerve palsy) most likely posterior communicating artery aneurysm.
If pupil size is normal then most likely (medical third nerve palsy) most likely diabetic or vasculitis cause and etc.
Third please demonstate the eye movement to see whether got other nerve involvement.etc 4th or 5th
If got 3rd ,4th and 5th, consider Graves disease(lid retraction )
cavernous sinus 3th 4th 6th and 5th may coexixst(demonstrate corneal reflex)
tolosa hunt (pain with no redness)

Newly added

From today onwards, i will regularly put in approach for medical disease for undergraduated and post graduate medical students.
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