Monday, May 27, 2013

Ceftaroline (Zinforo) a new toy for MRSA skin infection ?


Ceftaroline- a new generation of cephalosporin
Bactericidal
Block PBP
Addictive to other antibiotic, least interaction
Professor Lipman
CANVAS study showed effective against MRSA  complicated soft tissue infection compared to vancomycin  and aztreonem. Study showed non inferiority to Vancomycin and aztreonem
Treatment 5-14 days
FOCUS I and II – study showed effective towards CAP. No clinical data regarding MRSA CAP.
New combination produce –ceftaroline + avibactem –enhanced gram –ve cover.