Saturday, February 23, 2013

Causes of short stature

Short stature is a diagnosis which will give you clue during clinical examination especially during inspection.
added with other sign . It will help on your diagnosis.

Short stature can be divided into proportional and disproportional
proportional
Growth hormone deficiency
systemic disease
constitutional delay
familial

disproportional
Turner syndrome
Achondroplasia
Osteogenesis imperfecta
Congenital hypothyroidism (normally low IQ)


Achondroplasia  is a common cause of dwarfism. It occurs as a sporadic mutation in approximately 75% of cases (associated with advanced paternal age) or may be inherited as an autosomal dominant genetic disorder.

Osteogenesis imperfecta is a congenital bone disorder.It happened  because of a deficiency of Type-I collagen

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