Causes of thrombocytopenia

Medical always related with your normal life even for causes for thrombocytopenia.
It is just like economic-supply and demand
In thrombocytopenia- if destruction excess or reduced production

Impaied production-
1) drugs=eg cytotoxic
2) virus infection-dengue, HIV
3) infection-leptospirosis
4)megaloblastic
5)MDS
6)leukemia,Myelofibrosis, aplastic anemia
7)solid tumour
summary-drug, infection , blood dyscrasia-MDS, leukemia and solid tumour infiltration to marrow

excessive dest
Immune mediated
ITP
drug induced-penicillins, Grp IIB-IIIa inhibitors
secondary immune-SLE, CLL, heparin)
post tranfusion purpura
DIVC
TTP

sequestration
splenomegaly
diluional
massive tranfusion

ITP

ITP (Immune thrombocytopenia purpura) is due to immune destruction of platlelet.
Ab coated plt removed following binding to Fc receptors on macrophages
ITP in children – acute, history of recent viral infection-varicella, measles
ITP adult- less acute, seen in women, may be asso with autoimmune disorders such as SLE, thyroid diseases
CLL and solid tumours
Infections with virus- HIV
Clinical- major bleed rare, easy bruising
Inv-FBC, bone marrow-increased megakaryocytes
Treatment-Plt> 30x 109 no urgent trt
First line- steroid 1mg/kg body wt
IV igG is effective if needed rapid rise
Second line-splenectomy
Third line –failed both then danazol, other immunosuppressive such as azathioprine,ciclosporin , mycophenolate mofetil